21. All of the following factors can drug except 7 a age v b. sex c. disease sta
ID: 202741 • Letter: 2
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21. All of the following factors can drug except 7 a age v b. sex c. disease states d. the drug's dose be a cause of inividiua genetie variation Matching Questions 22. half life of drug 23. first pass metabolism 24. drug microsomal metabolizing system 25, blood brain barrier 26. loading dose 27. bioavailability 28. drug tolerance 29, drug dependence b. a lipid barrier caused by tight junctions in the cells that line brain capillaries c. the percentage of a dose that is absorbed into the blood and tissues. d. the time it takes for the blood drug concentration to decrease by half e. state where stopping of the drug will cause withdrawal symptoms f the cytochrome p450 enzymes g. the absorption, distribution, metabolism and excretion of drugs h. metabolism of orally administered drug by the liver before it enters the general a. a decreased drug effect after repeated drug administration (blood) circulation. An initial dose administered to rapidly achieve therapeutic drug concentrations i. True False Questions 31. A reason why oral administration is the safest is because not as much drug is absorbed by F the oral route than other routes of administration. T 32. Drugs must be dissolved to be absorbed from the gastrointestinal tract. T F 33. Drug distribution can be slowed by very high plasma protein binding of drugs. TExplanation / Answer
22. Half life of a drug - the time it takes for the blood drug concentration to decrease by half.
23. First pass metabolism - the time it takes for the blood drug concentration to decrease by half
24. Drug microsomal metabolizing system - cytochrome p450 enzyme
25. Blood brain barrier - a lipid barrier caused by tight junctions in the cells that line brain capillaries.
26. Loading dose - the initial dose adminstered to rapidly achieve therapeutic drug concentration
27. Bioavailability - metabolism of orally adminstered drug by the liver before it enters the general circulation
28. Drug tolerance - a decreased drug effect after repeated drug administration.
29. Drug dependence - a state where stopping of the drug causes withdrawl symptoms
30. Pharmacokinetics - absorption, metabolism distribution and excretion of drugs
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