-6 -5 -4 -3 -2 -1 0 25. Based on the sequence logo, which position of the peptid

Question

-6 -5 -4 -3 -2 -1 0 25. Based on the sequence logo, which position of the peptides have the highest conservation? .a. position 0 b. position -1 c. position -2 d. position -3 d. position -4 26. Based on the sequence logo, which statement is false about the peptide-binding site on PDZ proteins? a. peptide-binding site is linear and extended. b. peptide-binding site has some hydrophobic residues to interact with position 0. c. peptide binding site has positive charge amino acids to recognize position 0 and -1. d. PDZ peptide binding site has positive charge amino acids to recognize position -4. e. All of the above.

Explanation / Answer

The answers are provided below in a sequential manner:

25) POSITION 0: because there is no mutation in that nucleotide whatsoever.

26) D) PDZ peptide binding site has a positive charge amino acids to recognize position -4 because the charge on both arginine and lysine ( position 4) at ph 7 is already positive, so positive-positive would repell each other.

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