It has been shown that dwarf phenotypes result from mutations in Pit-1gene. Muta

Question

It has been shown that dwarf phenotypes result from mutations in Pit-1gene. Mutation of the Pit-1 gene results in hypoplasia of the pituitary gland and deficiencies of GH, PRL and TSH secretion. What phenotypic characteristics can be identified in these cases? What treatment can be the most beneficial?

When pituitary tumors develop in an individual they often arise from the proliferation of one particular endocrine cell phenotype. Among the most common of these microadenomas (benign tumors) are prolactinomas, which produce excess prolactin. What would be likely physiological symptom of a prolactinoma? What method could be used to confirm the presence of high levels of prolactin in the bloodstream of an individual with prolactinoma?

Explanation / Answer

2.When pituitary tumors develop in an individual they often arise from the proliferation of one particular endocrine cell phenotype. Among the most common of these microadenomas (benign tumors) are prolactinomas, which produce excess prolactin. What would be likely physiological symptom of a prolactinoma? What method could be used to confirm the presence of high levels of prolactin in the bloodstream of an individual with prolactinoma?

Ans-

Symptoms of Prolactinoma-

In women:

In men :

Mass Effect:

c) a

Chronic hyperprolactinemia

Diagnosis of Prolactinoma-

            Determine the prolactin level through a blood test is considered as the diagnosis of prolactinoma. Other possible causes of prolactinoma except the prolactin include pregnancy,
stress, low thyroid function, kidney failure and liver failure. The prolactin level determine the size of the tumor because large tumors have high levels of prolactin. If a prolactinoma is determined on the basis of clinical symptoms, then the test should be repeated using a diluted sample of blood called "Hook Effect".

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