Considering the Metabolic pathways of Mycoplasma bacteria: A. Briefly evaluate t

Question

Considering the Metabolic pathways of Mycoplasma bacteria:

A. Briefly evaluate the metabolism of the organism. How do they make PMF, ATP and reducing power? Do they have a broad or a narrow metabolic capacity?

B. How would deleting the TCA cycle affect this organism?

C. What about a mutation in the quinol binding site of the bc1 complex (Complex III) so that it could not accept a quinol? D. What about a mutation in the gene that encodes glyceraldehyde-3-P dehydrogenase (the enzyme that catalyzes the oxidation of G-3-P)?

Explanation / Answer

c)  a mutation in the quinol binding site of the bc1 complex (Complex III) leads to impaired growth.

D) It has been seen that some proteins play important role in bacteria's pathogenesis. The gene encoding glyceraldehyde-3-P dehydrogenase, enzyme used in glycolytic pathway is important for the bacterial virulence.

It has been seen that the mutation of gene encoding glyceraldehyde-3-P dehydrogenase leadto -

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