Please place the following features of the double-stranded break model of homolo

Question

Please place the following features of the double-stranded break model of homologous recombination in the correct order from first to last. (1-7)

Holliday junction resolution followed followed by mismatch repair if necessary

Template switching and completion of the establishment of two Holliday junctions

Template switching followed by D-loop formation

Precise alignment of the strands to be recombined

Enzymatically generated double stranded break in one of the two DNA molecules to be recombined

Enzymatic trimming around the double stranded break to generate single stranded overhangs on each side of the break

Extension of one of the single stranded overhangs followed by invasion into the DNA duplex of the other molecule that the elongating molecule is aligned with

Explanation / Answer

1. Enzymatically generated double-stranded break in one of the two DNA molecules to be recombined

2. Enzymatic trimming around the double-stranded break to generate single-stranded overhangs on each side of the break

3. Extension of one of the single-stranded overhangs followed by invasion into the DNA duplex of the other molecule that the elongating molecule is aligned with

4.. Template switching followed by D-loop formation

5. Precise alignment of the strands to be recombined

6.Template switching and completion of the establishment of two Holliday junctions

7. Holliday junction resolution followed by mismatch repair if necessary

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