Given info: p15 is an integral membrane protein,the complete amino acid sequence

Question

Given info: p15 is an integral membrane protein,the complete amino acid sequence of p15 contains 7 putative transmembrane domains,agonist-stimulation of p15 receptor-expressing cell lines results in decreases in forskolin-induced increases in cAMP accumulation and is dependent on a heterotrimeric G protein.

Which of the following actions which occur in response to binding of an agonist to a GPCR like 15, can be mediated by beta-arrestin:

You may choose more than one answer.

Explain both why you made your choices and why you did not select the others.

a) direct inhibition of GTPase activation

b) internalization of the GPCR via clathrin-coated pits

c) activation of protein kinases via scaffold function of beta-arrestins

d) phosphorylation of GPCR

Explanation / Answer

These molecules are involved in direct inhibition of GTPase activation.

Because signal molecule binds to the receptor and then activates G protein which form cyclicAMP and do further signalling.

Beta arrestin molecule arrest the gpcr receptor and then do internalization by update in glittering coated vesicles and then permanent inhibition of gpcr signalling.

option C is not valid for these innovative components.

Phosphorylation of GPCR also affects the signalling process but not that much as arrestin performs.

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