1. What is a prosthetic group? 2. What is the prosthetic group in myoglobin? 3.
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Question
1. What is a prosthetic group? 2. What is the prosthetic group in myoglobin? 3. What is the oxidation state of the Fe in oxymyoglobin? 4. What kind of bonds hold heme to myoglobin? 5. What feature of myoglobin protects the iron from water? 6. What amino acid in myoglobin reduces the ability of the heme to bind carbonmonoxide? 7. What is the function of the amino acid side chains which are on the surface of myoglobin? If a particular myoglobin has a P50 of 30, what is the fractional binding at 30 torr of 02 pressure? What is the fractional binding at 60 torr of 02 pressure? 8. At what pressure of O2 will a solution of myoglobin have 100% of the myoglobins bound with 02? 9. 10. How many oxygens (02) can a single myoglobin molecule bind?Explanation / Answer
1. A prosthetic group is a specific non protein group that is attached with the proteins for their biological activities.
2.The myoglobin has a heme group as the prostheic group which is a small yet an important molecule of myoglobin.
3.In myoglobin, the heme group consists of an organic part and an iron part in its centre. When the iron has an oxidation state of +2 it forms oxymyoglobin where the Fe binds to the oxygen molecule which means the Oxidation state of Fe in oxymyoglobin is +2.
4. In myoglobin, the heme group consists of an organic part namely protoporphyrin IX and an iron part. It is an iron ligand coordinated with four nitrogens and oxygen and another nitrogen. There is a coordinate covalent bond between the iron atom and a nearby nitrogen atom meaning, in myoglobin the heme is covalently linked with histidine.
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