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7 of 8 Lecture 7 Material 1. The degree of penetration of a toxicant depends on

ID: 205499 • Letter: 7

Question

7 of 8 Lecture 7 Material 1. The degree of penetration of a toxicant depends on a) Size/shape of toxicant. b) Lipophilicity/hydrophilicity c) Solubility reactivity. d) All of the above. 2. Which exposure pathway has the fastest uptake in the human body? a) Intravenous b) Intramuscular c) Subcutaneous d) Inhalation 3. Zero order kinetics refers to: a) Rate of elimination is directly proportional to concentration or amount of chemical b) c) d) present at that time Rate remains constant and independent of concentration or amount of chemical Rate is dependent of concentration or amount of chemical None of the above is correct © 2009 Jers and Bartlett Pullibrs, LLC (wwwapuheeno

Explanation / Answer

1) All of the above - The degree of penetration of a toxicant depends on melting point, boiling point, vapour pressure, dissociation constant (pKa), Nernst partition coefficient (P), activation energy, heat of reaction, reduction potential, ionization potential, dielectric constant, dipole moment, mass:charge ratio, atomic charge, bond energy, resonance energy, electron density, molecular reactivity, molecular volume, shape and surface area, substructure shape, molecular reactivity number of bonds number of rings and extent of branching.

2) Inhalation - Inhaling a toxicant will enter the bloodstream with minimal immunological barriers. It is also the easiest pathway. Once inhaled, the toxicant will be pumped by the heart along with the oxygenated blood, which will immediately reach the whole body.

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