10-Q5: In vertebrate CNS neurons, synapses are on dendritic spines. Most of the

Question

10-Q5: In vertebrate CNS neurons, synapses are on dendritic spines. Most of the postsynaptic receptors are on the spine head, which are attached to the dendrite through a very small spine neck. What is the consequence of this small neck?

Q6 At chemical synapses, electrical signals are converted to chemical signals at the presynaptic axon terminal in the form of neurotransmitter release. The binding of neurotransmitters to receptors on the postsynaptic membrane can directly or indirectly trigger changes in the electrical properties of the postsynaptic neuron. How is information transmitted between presynaptic and postsynaptic neurons at electrical synapses?

10-Q7: Explain the role of connexins in electrical synapses.

Explanation / Answer

Ans 5- Becaus eof its size constraint, not many studies have been conducted on it. However it has been proposed that:

a) They increase the number of connection between different neurons

b) They differentiate the nature of synapse of one cell from the other

c) It might reduce the flow of current or the chemicals from the spine head into the dendritic shaft.

d)By having an hold over the calcium ions it can regulate the downstram actions of synaptic inputs.

Ans 6- Neurons communicate with each other via junctions called as synapses. Two neurons communicate by the measure of electrical signals. These electrical signals are generated due to differences in the concentration of ions. Thus the message transferred is due to chemicals. A concentration gradient generates an action potential which in turn triggers the presynaptic neuron to release. These neurotransmitters are chemical messengers who go and bnd on to the receptors and generate the downstream action. Their binding might initiate either a postive or negative regulatory action.

Ans7- Connexins, being a major part of gap junctions take part in volatge gating, charge selectivity, autocrine and paracrine signalling, hence playing a major part in synapse and thetransfer of information from one neuron to another.

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