An individual bears a dominant mutation that leads to dramatic increase in nondi

Question

An individual bears a dominant mutation that leads to dramatic increase in nondisjunction of all chromosomes during meiosis. this person, perhaps not surprisingly, displays reduced fertility, manifested as an increase in early miscarriage. what probably explains this subfertility?

1. high levels of aneuploidy among their progeny.

2. Increased movement of transposons in their gametes.

3. production of dicentric bridges and loss of acentric chromosome

4. Heterozygosity for a balanced translocation.

Explanation / Answer

Answer: High level of Aneuploidy among their progeny

Non DIsjunction of chromosomes during meiosis leads to non separation of homologous chromosomes during gamete formation. This leads to formation of gametes with abnormal number of chromosomes leading to aneuploidy in the next progeny that manifests itself as increased rate of miscarriage

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