Mutations that inhibit Rb gene expression will have what effect on cell prolifer

Question

Mutations that inhibit Rb gene expression will have what effect on cell proliferation?

E) There will be no effect on cell proliferation; only apoptosis occurs.

Thanks,

A) Cells will proliferate less because growth factors are absent. B) Cells will proliferate more because growth factors are produced in excess. C) Cells will proliferate more, regardless of growth factor concentration. D) Cells will proliferate less, even if excess growth factors are present.

E) There will be no effect on cell proliferation; only apoptosis occurs.

Thanks,

Explanation / Answer

Rb gene is a tumor suppressor . So its actually regulates cell proliferation. When Rb protein gets phophorylated it will inhibit cell growth. Rb inhibits the cell proliferation by controlling cell cycle.

Thus mutation in Rb gene will lead to

C) Cells will proliferate more, regardless of growth factor concentration

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