Lab Assignment – Lovin’ the Antibodies (12 points) So…in lecture, we’ve been stu

Question

Lab Assignment – Lovin’ the Antibodies

(12 points)

So…in lecture, we’ve been studying specific defenses of the host – ah, the power of antibodies! Antibody-antigen interactions are the bases for many, many diagnostic tests. We’ll explore a few in this assignment.

First, the Rapid A Strep Test is a common clinical test – anyone ever had Strep throat? Check out the following website, work through the simulation, and answer the questions below. (6 points)

http://learn.chm.msu.edu/vibl/content/rapidstrep/rapid_strep/index.html

1. Is swab #1 positive or negative?

2. Is swab #2 positive or negative?

3. What disease is this test used to detect?

4. Describe why this test is called a “lateral flow immunoassay”? (Be specific!)

5. Does this test detect antigen or antibody from the patient sample?

6. Would this Rapid A Strep test be considered direct or indirect? Why?

_____________________________________________________________________________________

Second, the Strep Latex Agglutination Test is used to identify various strains of Streptococcus. Check out the following website, work through the simulation, and answer the following questions. (6 points)

http://learn.chm.msu.edu/vibl/content/latexaglu/Latex_Agglutination_Test/index.html

1. What is a Lancefield group and why do we care? You’ll need to do a bit of extra digging to answer this question…but, please do not copy and paste from Wikipedia, or any other internet site!

2. Who proposed them?

3. What "group" is sample 1? You have to do the controls first. Then, use the key on the left-hand side of the screen to interpret the results.

4. What "group" is sample 2? You have to do the controls first. Then, use the key on the left-hand side of the screen to interpret the results.

5. What component in solutions A, B, C, F, and G allows this test to work - Be specific!

6. Describe why this test is called an agglutination reaction.

Explanation / Answer

Rapid strep test

3.pharygitis is the disease used to test .

4.it is called lateral flow because it involves control line which shows wether this device is working properly also it can be tested by patient.this is immunoassay because antigen antibody binding is involved

5.This test detects the antigen for streptococcus in the patient.

6.This is a direct test because the colored line in the test show that the patient is positive and no colour in the test shows that the patient is negative.

Strep agglutinagtion test

6.this test is agglutintion because the antibody produced by the patient will agglutinate with the anigen which present in form of beads.

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