Many cancers exhibit unique metastatic patterns; for example, breast cancers mos

Question

Many cancers exhibit unique metastatic patterns; for example, breast cancers most frequently metastasize to the bone marrow, lungs, liver, and brain, while colon cancers most frequently metastasize to the liver, lung, and peritoneum. Describe the key physiologic properties that influence where tumor metastases will occur.

3. Many cancers exhibit unique metastatic patterns; for example, breast cancers most frequently metastasize to the bone marrow, lungs, liver, and brain, while colon cancers most frequently metastasize to the liver, lung, and peritoneum. Describe the key physiologic properties that influence where tumor metastases will occur. (5 pts.)

Explanation / Answer

Inflammation. Systemic Inflammation can lead to tissue damage and cause epigenetic changes. Anchorages are severed and allow cell migration Sites where secretion of tissue dissolving enzymes take place, again allowing migration of cells Angiogenesis: Rapid development of new blood vessels allow for the spread of cancerous cells Chemokines and TGF-Beta also tend to be specific for metastasis

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