Academic Integrity: tutoring, explanations, and feedback — we don’t complete graded work or submit on a student’s behalf.

6. You are studying the effects of mutations caused by the new compounds in ques

ID: 207526 • Letter: 6

Question

6. You are studying the effects of mutations caused by the new compounds in question 5. You expose Drosophila larvae to either Com1, Com2 or Com3, then collect the adult males that developed from exposed larvae, mated them with unexposed females, and then counted the number of mutant F1 flies produced by each male. You obtained the following results: Group Control Com1 Com2 Com3 # of Offsprin 20,456 21,379 19,321 19,938 35 54 Calculate the mutation rates of the control group and the three groups exposed to the new compounds. Com2: fa family with Huntington disease, a dominant condition

Explanation / Answer

The spontaneous point mutation rate in Drosophila is 2.8* 10^-9 per site per generation calculated among 12 mutants

Calculated for 35 mutants – 8*10^-9

Calculated for 54 mutants -1.26*10^-8

Calculated for 90 mutants - 2*10^-8

(Number of mutant off springs / number of off springs) *100 = percent mutant off springs

%mutant off springs                                

control 0.004888541

0.004888541 compound1

0.279488639 compound2

0.279488639 compound3