In the following graphs, the cellular response, as measured in real time (x-axis
ID: 207683 • Letter: I
Question
In the following graphs, the cellular response, as measured in real time (x-axis, hours) by the % activation of a certain active effector protein (y-axis), is plotted for five cell types (A to E) that are treated with three different concentrations of a signal molecule. During the time period indicated by the horizontal gray bar underneath the X-axis, the signal molecule is present in the culture media at a concentration of 1 nM (dotted line), 5 nM (gray line), or 25 nM (solid line). Analyze the graphs then answer the following question.
1. Which of the cell types A to E shows the lowest sensitivity to the signal ?
2. Which of the cell types A to E shows a response with the highest persistence ?
3. Which of the cell types A to E shows the fastest signal adaptation ?
1 100 100 T 0 0 0) 61 100 100 0 0 0) 0 100 T 0) 0 Time (hour)Explanation / Answer
1. D - lowest sensitivity to the signal
2. A - response with the highest persistence
3. A, B, C - fastest signal adaptation
4. C - shows differential responses over the widest range of signal concentrations tested.
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