Archeological evidence suggests that Neanderthals might have been aware of the m

Question

Archeological evidence suggests that Neanderthals might have been aware of the medicinal properties of plants over 60,000 years ago. Imagine you are a modern-day ethnobotanist and have identified a compound in an extract from fossilized tree pollen that binds to the alpha subunit of the most common G-proteins. To test how (and whether) it affects the activity of Ga, you treat cultured liver cells with your purified compound along with epinephrine. of the following could be the mechanism of action of the compound? It could inhibit the GTPase activity of Ga. OIt could decrease the affinity of Ga for GDP It could cause Ga to bind more tightly to adenylate cyclase. 0 It could prevent Ga from binding to the epinephrine receptor.

Explanation / Answer

Option D is correct.

Inhibiting GTPase activity will make Gprotein to bind to adenyl cyclase permanently so that Glucose is produced continuously.

Decreasing the affinity for GDP will increase the chance of binding of GTP to G protein which in turn will activate the pathway.

If G protein binds with adenyl cyclase it will stimulate it.

But if the Gprotein is prevented from binding with epinephrine receptor then the receptor can't activate exchange the guanine nucleotide to Gprotein for activation. Hence the Gprotein remains in inactive state.

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