Many metabolic disorders have similar symptoms because of the connections betwee
ID: 208437 • Letter: M
Question
Many metabolic disorders have similar symptoms because of the connections between pathways. Lactate dehydrogenase deficiency and a deficiency in phosphofructokinase-1 in muscle can have similar symptoms of exercise intolerance, including fatigue and muscle pain during strenuous exercise. Individuals with phosphofructokinase-1 deficiency have more severe symptoms. Treatment for both individuals includes avoidance of high-intensity exercise. Along with other similar symptoms, both deficiencies display abnormal lactate levels during exercise. In order to distinguish between these two disorders, a physician could test the patient's lactate levels during exercise before and after administering glycerol (which can be converted to dibvdroxvacetone phosphate). What would be the expected results if this test were performed? 2. Lactate levels would be low after intense exercise if the patient has a deficiency in muscle phosphofructokinase-1 and high if the patient has a deficiency in lactate dehydrogenase. Lactate would increase after glycerol was administered if the patient has a deficiency in muscle phosphofructokinase-1 but not if the patient has a deficiency in lactate dehydrogenase. Lactate levels would be high after intense exercise in both disorders. Lactate would increase after glycerol was administered if the patient has a deficiency in lactate dehydrogenase but not if the patient has a deficiency in muscle phosphofructokinase-1. Lactate levels would be low after intense exercise if the patient has a deficiency in muscle phosphofructokinase-1 and high if the patient has a deficiency in lactate dehydrogenase. In both disorders, lactate would increase after glycerol was administered. Lactate levels would be low after intense exercise in both disorders. Lactate would increase after glycerol was administered if the patient has a deficiency in lactate dehydrogenase but not if the patient has a deficiency in muscle phosphofructokinase-1 Lactate levels would be low after intense exercise in both disorders. Lactate would increase after glycerol was administered if the patient has a deficiency in muscle phosphofructokinase-1 but not i the patient has a deficiency in lactate dehydrogenas a. b. c. d. e.Explanation / Answer
Answer - B
1.Lactate level is high either of the deficiency during intense excerise.
2. If glycerol is administered if patient has deficiency of PFK1 leads to decrease in lactate concentration. Because glycerol converted to dihydroxyacetone phosphate to glyceraldehyde 3 phosphate. Due to deficiency of PFK1, glyceraldehyde 3 phosphate favours the gluconogenesis and leads to formation of glucose. So, in PFK1 deficiency glycerol converted to glucose.
If presence of PFK1, favour the glycolysis so glycerol makes a glycolytic pathway and form lactate. And further lactate dehydrogenase makes accumulation of lactate in the cell.
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