The graph below is directly from the exam. The question was regarding the inacti

Question

The graph below is directly from the exam. The question was regarding the inactivation state of Nav channels at different voltages. One part of the question asked you to figure out how it is that this graph shows lots of inactivation at -40mV even though during an action potential the largest Na current is at -40 mV. Explain to me how the data shown in this graph was collected AND how this methodology is very unnatural AND what this graph would look like if the methodology was changed so that each test- voltage was only held for 0.5msec rather than the 30msec that was actually used (make your own graph below the one diagramed). -100 70-40 -10 Membrane Voltage (mV)

Explanation / Answer

Sodium channels intercede quick depolarization and lead electrical driving forces all through nerve, muscle and heart. This paper audits the connections between sodium channel structure and capacity.

Sodium channels have a measured design, with particular locales for the pore and the entryways. The partition is a long way from supreme, nonetheless, with broad connection among the different parts of the channel. At a sub-atomic level, sodium channels are not static: they move broadly over the span of gating and particle translocation.

Sodium channels tie neighborhood analgesics and different poisons. Now and again, the significant destinations have been in part distinguished.

Sodium channels are liable to control at the levels of interpretation, subunit connection and post-translational change (remarkably glycosylation and phosphorylation).

Voltage-gated sodium channels are in charge of activity potential start and spread in edgy cells, including nerve, muscle, and neuroendocrine cell writes. They are additionally communicated at low levels in nonexcitable cells, where their physiological part is vague. Sodium stations are the establishing individuals from the particle station superfamily as far as their revelation as a protein and assurance of their amino corrosive arrangement . This article exhibits a prologue to their biochemical, atomic, and hereditary properties, physiological parts, and pharmacological importance.

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