23. You have discovered a new enzyme that you name Pac-Manase that breaks down P

Question

23. You have discovered a new enzyme that you name Pac-Manase that breaks down Pac-dot substrates (see figure below). You determine that the following potential interactions may occur between amino acids (3 letter abbreviation in blue) in the enzyme's active site and its substrate (in light green in figure below). At Gln each site between the chemical group (in Ho black) on the substrate and the closest side chain of an amino acid (in blue) on the enzyme, Pac-Manase, determine if a Pac-Manase Asp H,N enzyme) Pac-dot (substrate) favorable interaction is likely to take place. A. Fill in the table: If a favorable between the amino acid and (9 pts total) Ile NH2 ys interaction is likely take place substrate functional group, circle the name for the strongest direct rg Yes (or No) (0.5 pt each) and fill in interaction. Choose from ionic bond, covalent bond, hydrogen bond and hydrophobic interaction (1 pt each). SEE AMINO ACID STRUCTURES ON LAST PAGE FOR HELP. Place your answers in the table on the answer sheet B. For all cases where a potential interaction seemed unfavorable, explain why. (1.5 pts) FILL IN TABLE for parts A and B ON ANSWER SHEET

Explanation / Answer

arginine- forms ionic bond (formed between carboxylate ion)

lysine- forms covalent bond (attack the electrophilic carbonand form covalent bond)

glutamine- forms hydrogen bond (highly hydrophilic)

isoleucine- forms hydrophobic interaction (can't form hydrogen bond)

aspartate- forms an unfavourable interaction

Related Questions

Navigate

• Browse (All)
• Browse 2
• Subjects

---

---

Integrity-first tutoring: explanations and feedback only — we do not complete graded work. Learn more.