9. (2pts) You are studying meiotic recombination in mice and have isolated vario
ID: 209536 • Letter: 9
Question
9. (2pts) You are studying meiotic recombination in mice and have isolated various mutations in the Spo11 gene. One mutation is a nonsense mutation in the first exon of Spo11. Another mutation is a missense mutation that results in temperature-sensitive allele of Spo11. A mouse that is heterozygous for the nonsense mutation (other allele is wildtype) is crossed with a mouse that is homozygous for the missense mutation, which has been kept at the permissive temperature from an early embryonic stage. Which of the following is a correct prediction of what phenotypes would be observed in the progeny from this cross? Assume Spo11 is haplosuffcient.
10. (2pts) If you perform the same cross as described in the question above, but the parent that is homozygous for the missense mutation was kept at the restrictive temperature from an early embryonic stage, which of the following is a correct prediction of what phenotypes would be observed in the progeny from this cross?Select ALL correct answers
All wildtype progeny if progeny are raised at the permissive temperature
All sterile progeny if progeny are raised at the permissive temperature
All wildtype progeny if progeny are raised at the restrictive temperature
All sterile progeny if progeny are raised at the restrictive temperature
No living progeny if progeny are raised at the permissive temperature
No living progeny if progeny are raised at the restrictive temperature
All wildtype progeny if progeny are raised at the permissive temperature
Explanation / Answer
9. Cross between one normal / non sense mutation heterozygous X missense mutation (T0 sensitive) homozygous
Offsprings has -
1. normal and missense mutation (T0 sensitive) - It is grown in permissive temperature so it will survive. All wildtype progeny if progeny are raised at the permissive temperature
2. non sense mutation and missense mutation
(T0 sensitive) - It is not able to grown in permissive temperature.
No living progeny if progeny are raised at the permissive temperature and No living progeny if progeny are raised at the restrictive temperature.
10.
1. normal and missense mutation (T0 sensitive) - It is grown in non permissive temperature so it will survive but become sterile. All sterile progeny if progeny are raised at the permissive temperature
2. non sense mutation and missense mutation
(T0 sensitive) - It is not able to grown in permissive temperature.
No living progeny if progeny are raised at the permissive temperature
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