choose the correct answer b. False 14. When repairing DSBs by homologous recombi
ID: 209714 • Letter: C
Question
choose the correct answer
b. False 14. When repairing DSBs by homologous recombination, there are 2 sources that can be used to provide information about the nucleotides that have been lost from the broken DNA. One source is the homologous chromosome, the other is? a. tracrRNA b. Cas9 c. An analogous chromosome d. A sister chromatid 15. When DSBs are repaired by homologous recombination, extension of the 3' overhang occurs before strand invasion. a. True b. False 16. As a repair mechanism, homologous recombination is used more often than NHEJ True False 17. The homologous DNA used to repair the DSBs created by CRISPR in the knockout cells was provided to the cells by the scientist. a. True b. FalseExplanation / Answer
14. Option D is correct.
The two sources that can provide sequence information during double-strand break repair are Homologous chromosomes and sister chromatids.
15. True.
When DSBs are repaired by homologous recombination, an extension of the 3' overhang occurs before strand invasion. A long ss DNA tail is generated during DSB repair which can invade the homologous strand.
16. True.
Homologous recombination is more efficient and less error-prone compared to NHEJ. NHEJ works to repair the damaged DNA in the absence of any homologous DNA and can be extremely error-prone.
17. Option D is correct.
The homologous DNA used to repair the DSBs created by CRISPR in the knockout cells was provided to the cells by the scientist. This is because CRISPR eliminates homologous sequences in the knockout mice.
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