You need to determine which degradable material to use as a tissue engineering s

Question

You need to determine which degradable material to use as a tissue engineering scaffold for repair of a critical- sized bone defect (i.e. a defect that would not heal on its own). You are planning to seed the scaffold with cells then implant it into the defect. While the cells proliferate and generate new bone, the scaffold will degrade and create void space into which the new tissue can grow. Would you prefer a scaffold material that breaks down via bulk degradation or surface degradation? Would you prefer for the scaffold to undergo hydrolytic or enzymatic degradation? Please explain each of your choices. 1. It will be preferable for the scaffold to undergo_ [answer 1] (bulk or surface)__degradation which is primarily [answer 2] (hydrolytic or enzymatic)in nature. The reason for this choice of material properties is [answer 31

Explanation / Answer

It will be preferable for the scaffold to undergo bulk degradation which is primarily hydrolytic in nature.

The reason for this choice of material properties is that the polymeric scaffolds undergo bulk degradation tend to break down the internal structure of scaffold thus reducing the molecular mass.

Though the size of scaffold becomes smaller the bulk structure will be maintained. This provides longer mechanical stability for the tissue to regenerate.

Hydrolytic degradation involves cleavage of hydrolytically sensitive bonds. The controllable degradation and restoration rates should match the rate of the tissue growth. This is biologically stable, and it can provide a permanent support to the patient.

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