8. For a-i, fill-in the blank with the appropriate molecule or response. (9 pts)

Question

8. For a-i, fill-in the blank with the appropriate molecule or response. (9 pts) a. as a result of somatic recombination b. and J gene segments that acts as a recognition site for somatic recombination C. d. during somatic recombination e. occurs the joint formed between V, D, J gene segments conserved DNA sequence motif located adjacent to V, D enzyme that covalently modifies and activates Artemis protein heterodimer that binds directly to DNA hairpins a tissue or organ in the body where somatic recombination heterodimer responsible for making the initial DNA cut a cell type(s) in which somatic recombination occurs during somatic recombination h. D, J gene segments during somatic recombination protein that adds N nucleotides to the joints between V, enzyme responsible for joining the DNA ends between V, D, J gene segments during somatic recombination

Explanation / Answer

a. Coding joints

b. Recoginition signal sequences (RSS)

c.DNA-PKcs (DNA -protein kinase catalytic subunits) , this enzyme cause cleavage in artemis after binding to it then activates the artemis

d.RAG complex made of RAG1 and RAG2

e.Bone marrow - is the site for somatic recombination

f.RAG1 enzyme role in V-D-J recombination sysytem

g. B-cells , because these are type cells which will be going to produce antibody diversity.

h.deoxynucleotidyl transferase enzyme, requires for the N nucleotides addition

i. Ligase, used for joining the two ends of DNA

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