Assume that a series of compounds has been discovered in Neurospora. Compounds A

Question

Assume that a series of compounds has been discovered in Neurospora. Compounds A-F appear to be members of an enzyme pathway. Several mutations have been identifhied an strains 1-4 each contains a single mutation. Shown below are five possible pathways Choose the pathway that best fits the data presented. [Growth in minmal supplements is shown by (+), no growth is shown by (o)) with a. b. A-> B C D E F A B C F D E d. A- B F E C D A-> B C D F E e. 33. Consider the pathway for synthesis of the amino acid arginine in Neurospora ARG-H ARG-E ARG-F ornithine citrulline argininoosucc mutant strain carries only a single mutation. Growth is shown by (+), no growth is sho wn by (o) Most mutants of Neutospora are grown in minimal media supplements as follows: Each nothing ornithine citrulline Indicate the correct strain/defective gene pairing. a. Strain b/ARG-F b. Strain a/ ARG-H c. Strain a/ARG-MF d. Strain c/ARG-E

Explanation / Answer

32. Answer E

Step 1: To identify this we need to take a expression of only one compound in a mutant strain. That could be the final product. Here strain 3 has only E. So he is the final product.

Step 2: We need to select 2 expression and it must contain E. The strain 2 contains both E and F. So F is the substrate for E.

Step 3 : Now select 3 expression and it must contain E and F. The strain 1 contains D, E and F. So D is substrate for F anf F is the substrate for E.

Step 4: Select 4 expression and it must contain D,E and F. The strain 4 contains C, D, E and F. So C is the substrate for D and so on.

order A - B - C - D - F - E

33. C - strain a/ ARG-F

We are growing the mutant strain in minimal media. In strain A addition of citrulline it not able to survive.
But add of arginosuccinate and argine gives a growth. So, ARG-F has a mutant to convert Citrulline to Arginosuccinate.

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