Which of the following statements logically explains the anticipation shown by D

Question

Which of the following statements logically explains the anticipation shown by DKC or why DKC arises at an earlier age in subsequent generations?

Which of the following statements logically explains the anticipation shown by DKC or why DKC arises at an earlier age in subsequent generations? ildren with DKC inherit shorter than average telomeres to begin with, and subsequently the normal shortening of telomeres during replication would result in even shorter telomeres at an earlier age. O DKC in these families arises at progressively younger ages in successive generations because of their abnormally early maturation of reproduction DKC becomes more severe in offspring due to faulty recombination events involving abnormal telomerase inherited from parents. Children of parents with DKC preferentially arise from gametes with defective perpetuated in their offspring. abnormal replication events associated with a defective telomerase. O telomerase, which proliferate more rapidly than normal gametes, and this trend is O The anticipation observed in DKC is the result of accumulating mutations caused by the

Explanation / Answer

The defective RNA component results in shortened telomeres. For individuals in subsequent generations who inherit the DKC, it is likely that these individuals also inherited shorter telomeres from the parent possessing the DKC allele .Once telomeres become too short, cells would normally undergo cell death (apoptosis), which likely cause the symptoms of DKC.In subsequent generations, telomeres may reach that critical length earlier, leading to an earlier onset of DKC.

so first and third options are more appropriate.

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