40 mv 4. (2 pts each) For a given neuron, you determine that the equilibrium pot

Question

40 mv 4. (2 pts each) For a given neuron, you determine that the equilibrium potential of Cr is -40 mv. a. Is the Cl concentration higher inside or outside the cell? b. Which direction would cr flow if you set the membrane potential to 0 ? Write in (into the cell) or out (out of the cell) c. Which direction would Cl flow if you set the membrane potential to -80 mV? Write in (into the cell) or out (out of the cell) You identify a drug that shifts the voltage dependence of voltage-gated sodium channels, sing them to open at a higher (less negative) membrane potential than usual.

Explanation / Answer

Ions are charged, say they are diffusing across a membrane due to a concentration gradient, as they accumulate on the other side of the membrane the potential developed will oppose the motion. The potential difference that counterbalances the movement of ions due to concentration difference is called the equilibrium potential.

a) Chlorine is higher on the outside of the cell

b)Chlorine will tend to flow into the cell because of the concentration gradient

c)Net Chlorine movement will stop at -40 mV itself as that is the equilibrium potential; a higher potential will cause the net movement of chlorine out of the cell

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