1. a. What molecule (be specific) does Zelboraf inhibit? (1 pt) b. Is this molec
ID: 210793 • Letter: 1
Question
1. a. What molecule (be specific) does Zelboraf inhibit? (1 pt) b. Is this molecule found in melanoma cells, normal cells or both? (1 pt) c. What do you predict about Zelboraf side effects, relative to chemotherapy? Briefly explain your answer. (2 pts) 2. Complete the table below for the treatment options that are likely to be successful for each of John and Rick, given that they have metastatic melanoma. (5 pts) Treatment Successful for John? Successful for Rick? Surgery Radiation Chemotherapy Zelboraf Keytruda 3. For each of the PRECISION treatments, EXPLAIN why it will/won't for each of John and Rick (in the table below). (4 pts) Why it will/won't work for John Why it will/won't work for Rick Precision Treatment 4. Who do you think has the better prognosis? Why? (2 pts)Explanation / Answer
a. Zelboraf is a B-Raf enzyme inhibitor. i.e., inhibiting the mutated BRAF Kinases and suppresses RAF-MEK-ERK signaling pathway
B,only melonoma cells
C. side effect of the drug:
At the maximum tolerated dose (MTD) of 960 mg twice a day 31% of patients get skin lesions that may need surgical removal.
The BRIM-2 trial investigated 132 patients; the most common adverse events were arthralgia in 58% of patients, skin rash in 52%, and photosensitivity in 52%. In order to better manage side effects some form of dose modification was necessary in 45% of patients.
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