Question 3: In this paper (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3393456/

Question

Question 3: In this paper (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3393456/#!po=45.2381) figure 5B. a) Which one of the two treatment options is more efficient at killing the ATCC 29213 bacterial strain.: ACH-702 at 16xMIC or Moxifloxacin at 32X MIC? b) What are the corresponding concentrations of drugs (in ug/ml)?

Question 4: Based on this report, if a patient would present a bloodstream infection with the ATCC strain 29213 S. aureus, which of the following antibiotics would you suggest?

a) Moxifloxacin, b) vancomycin, or c) linezolid

Briefly justify your choice, based on data presented in the two documents.

Question 5: To increase the chances of survival of the patient (described above), the physician suggests to target two distinct mechanisms of action, and propose to treat the patient with ciprofloxacin and tetracycline. Do you think that it is a good idea?

PMC full text: Antimicrob Agents Chemother 2012 Juli 56(7): 3812-3818 doi: 10 1128/AAC 00092-12 Copyright/LicenseRequest Fig 5 8 A 109 10 107 106 105 104 103 109 10 107 P106 105 104 103 0 1 2 3 4 56 24 26 0 1 2 3 4 5 6 24 26 Time (hr) Time (hr) ACH-702 and moxifloxacin activity against growth-arrested S. aureus ATCC 29213. Control exponential-phase and cold-arrested cells (A) or cells growth arrested by addition of the protein synthesis inhibitor erythromycin (B) were incubated with or without ACH-702 at multiples of the MIC and with moxifloxacin at 32x MIC. The cold-arrested cells were incubated at 0°C for 24 h and then shifted to 37°C for 2 h (A) Symbols: *, growth control.. ACH-702 at 2x MIC: .. ACH-702 at 4x MIC: A. ACH-702 at 8x MIC: . ACH-702 at 16x MIC; , moxifloxacin at 32x MIC. Similar results were obtained with replicate experiments

Explanation / Answer

3. 16X MIC is better at killing the particular strain. the concentration would be 16 times the MIC value (0.008) which is 0.128 g/ml (in the paper 0.125 is written)

4. Moxifloxacin (refer to fig 2 in the paper). This is because when all three antibiotics were administered at a same concentration, then moxifloxacin reduced the CFU from 107 to 10within 6 hours whereas the other showed a bacteriostatic effect by this time.

5.

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