6-Mercaptopurine (6-MP) is an anticancer chemotherapy drug that is categorized a

Question

6-Mercaptopurine (6-MP) is an anticancer chemotherapy drug that is categorized as an antimetabolite. 6-Mercaptopurine functions by mimicking adenine in the body. This drug is used to treat acute leukemia. NH2 SH adenine 6-mercaptopurine Arrange the process through which 6-mercaptopurine mimics adenine in the body and inhibits cancer cell growth. Rank the mechanism of actions from first step to last step. To rank items as equivalent, overlap them. View Available Hint(s) Reset Help First step Last step for adenine in the nucleotides used to build RNA and DNA DNA synthesis Cancer cell multipl cation slows down. inhibit adenine and guanine incorporation into DNA O The correct ranking cannot be determined.

Explanation / Answer

While 6-Mercaptopurine allows its wrongful incorporation in DNA it also interferes negatively with purine synthesis by consequently inhibiting glutamine-5-phosphoribosylpyrophosphate amidotransferase, an enzyme of de-novo purine synthesis. Hence both "6-Mercaptopurine substitutes for adenine..." and "pseudonucleotide inhibit...." are the first steps of two pathways by which the cancer cell metabolism is affected by AFFECTING DNA SYNTHESIS

Hence the correct order is

"6-Mercaptopurine substitutes for adenine..." and "pseudonucleotide inhibit...." = 1

"DNA SYNTHESIS IS SLOWED DOWN" = 2

"cancer cell metabolism slows down" = 3

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