The growth factor Dev1 stimulates the proliferation of cultured chicken cells. T
ID: 211272 • Letter: T
Question
The growth factor Dev1 stimulates the proliferation of cultured chicken cells. The receptor that binds Dev1 is a receptor tyrosine kinase (RTK), and many chicken tumor cell lines have mutations in the gene that encodes this receptor. Which of the following types of mutation would be expected to promote uncontrolled cell proliferation? (A) a mutation that prevents dimerization of the receptor (B) a mutation that destroys the kinase activity of the receptor (C) a mutation that inactivates the protein tyrosine phosphatase that normally removes the phosphates from tyrosines on the activated receptor (D) a mutation that prevents the binding of the normal extracellular signal to the receptor
Explanation / Answer
Which of the following types of mutation would be expected to promote uncontrolled cell proliferation?
C) a mutation that inactivates the protein tyrosine phosphatase that normally removes the phosphates from tyrosines on the activated receptor.
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