The Michaelis constant, Km, of metabolic enzymes can be near the cellular concen

Question

The Michaelis constant, Km, of metabolic enzymes can be near the cellular concentration of substrate for
some enzymes and far from the normal concentration for others. Choose the statement that best states the
reason for this variation in kinetic constants.
A) The rate of many enzyme steps can change quickly with small increases or decreases of substrate.
B) Isozymes may have different Km values for the same substrate to respond to changing cellular
conditions.
C) The maximal velocity, Vmax, can be obtained at all times
D) A and B
E) A, B, and C

Explanation / Answer

B) Isozymes may have different Km values for the same substrate to respond to changing cellular conditions.

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