The Michaelis-Menten equation models the hyperbolic relationship between [S and

Question

The Michaelis-Menten equation models the hyperbolic relationship between [S and the initial reaction rate (Vo) for an enzyme catalyzed, single substrate reaction: E S ESE P. The model can be more readily understood when comparing three conditions: [SKKm [S]-km, and [Sp>K,- Match each statement with the condition that it describes. Note: "Rate" refers to initial velocity (Vo) where steady state conditions are assumed; [Etotal refers to the total enzyme concentration, and [Efree] refers to the concentration of free enzyme. Not true for any of these conditions almost all active sites are empty ES] is much higher than [Efreel rate is half of the maximum rate [E free] is about equal to Etoteal reaction rate is independent of IS increasing IEsotal will lower K

Explanation / Answer

[S]=Km- [ES] is much higher than Efree] reaction rate is independent of [S]

[S]<<Km - Almost all active sites are empty [Efree] is about equal to [Etotal]

[S]>>Km– Rate is half of the maximum rate increasing [Etotal]will lower Km

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