Given are the reactions of the glycolysis pathway. The reactions are numbered 1-

Question

Given are the reactions of the glycolysis pathway. The reactions are numbered 1-10, however they are not in sequence. Identify the ATP consuming reaction(s). CHOPO, —O ,POH Ho/on HOPO,7 , 2-phosphoglycerate 20,PO 0 CH,0Poz? 1,3-bisphosphoglycerate OO TOPO,27 phosphoenolpyruvate 0 0 H-OH CHOPO? 3-phosphoglycerate OH fructose-6-phosphate OH glucose-6-phosphate -oo - CH,OPO, oo H--OPO,27 CH,OH 2-phosphoglycerate 3-phosphoglycerate . CHOPO, , HO) “,, 3 3 VOH 20,POH,Co , fructose-6-phosphate , OH fructose-1,6-biphosphate CH,OPO,2 HO H CH,OPO,27 glyceraldehyde-3- phosphate 20,POO HOM CH,OPO, 1,3-bisphosphoglycerate KOH KOH OAN OH glucose ON / OH dihydroxyacetone phosphate H0 H- CH,OPO,? glyceraldehyde- 3-phosphate ºo,POH, C o., CH,OPO,? Ho7 10 glucose-6-phosphate Oo H OPO,2 - . OH ,, H OH + CH,OH ,, glyceraldehyde dihydroxyacetone -3-phosphate phosphate phosphoenolpyruvate Pyruvate fructose-1,6-biphosphate

Explanation / Answer

Glycolysis aims to convert glucose to Pyruvate. This pyruvate is then transported to mitochondria for TCA cycle followed by generation of ATP using electron transport chain. The correct sequence of reactions is 4, 6, 3, 10, 8, 9 , 2, 7, 1,5.

As we can see in reaction 2, 1,3bis phosphoglycerate reacts to give 3 phosphoglycerates by loosing one inorganic phosphate to ADP forming ATP. 2 ATPs are produced this way per glucose.

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