I don’t think my answers are right Question 8 (1 point) The protein p53 is part

Question

I don’t think my answers are right Question 8 (1 point) The protein p53 is part of a mechanism to halt cell division if DNA has been damaged--e.g., by ultraviolet radiation (sun damage). How does this mechanism work? When DNA damage is detected, a molecule is activated that phosphorylates p53, thereby activating p53. a Activated ps3 acts as a transcription factor that that turns on genes that produce a protein (let's call it p21) that can block cyclin-CDK binding. If cydin is blocked from binding CDK, CDK will not be able to phosphorylate the molecules that allow the cell to progress from G1 to S; cell division is paused/halted This mechanism is part of the S-G2 checkpoint. Save Question 9 (1 point) Which of the following statements are correct about the cydin and CDK molecules that regulate the cell cycle? The level of cydins rises and falls throughout the cell cycle. Cyclins are proteins that are often released in response to the signaling pathways that promote cel division 3 cydlins are kinases that are activated when phosphorylated

Explanation / Answer

Answer

8. B and C

B. p53 activates transcription of p21 = CIP family inhibitor --> p21 inhibits cyclin-CDK inhibitors --> stops cell cycle progression

C.If cyclin is blocked from binding CDK, CDK will not able to phosphorylate the molecules that allow the
cells to progress from G1 to S, cell division is halted

9. A and D

A. Level of cyclins rises and falls throughout the cell cycle.

D. Cyclins activates CDKs

Cyclins are a family of proteins that have no enzymatic activity of their own but activate CDKs by binding to them.

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