Immunology Case Study 1 (Q 1-9) *Dottie Oblonski was doing well in her first yea

Question

Immunology Case Study 1 (Q 1-9) *Dottie Oblonski was doing well in her first year of university when she developed a cough and diarrhea. She felt very tired an achy and went to bed early in her dormitory room. The next morning she woke early with severe headache, stiff neck and high fever. Her roommate called the ambulance and she was rushed to the hospital. A check of her blood pressure showed that it was very low (70/40). Blood cultures were grown and found to be positive for Neisseria meningitides (meningococcus). The cerebrospinal fluid test was clear of any organisms, but the had a much high number of white blood cells Her blood white-cell count was determined and had 90% neutrophils and low number of lymphocytes. Intraveneus antibiotic therapy was administered and she improved over the next 48 hours. Which of the following events are most likely to occur in the first 8 hours of the medical episode? 1. a. Pathogens are engulfed by macrophage b. Pathogen infected cells are killed by natural kilter cells c. T cells are recruited to engulf infect cells d. Both A and B are correct e. Both B and C are correct ? nuring the first 8 hours the cytokines produced by phagocytes may lead to

Explanation / Answer

The genetic test of Dottie's elder sibling shows that the classical pathway of leptin is severely affected. The presence of C1q and C1s proves this. Since 'Leptin regulates metabolism in the body and body immunity, Martha might have gained weight or blood test showed high sugar level. This external and internal diagnosis might have led the doctor to infer that the classical pathway might have been severely affected.

Increasing the level of cytokine and JAK2 tyrosine kinases can arrest the multiplication of C1q and C1s and prevent the patient from becoming obese.

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