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Why do cells maintain low fidelity, error prone DNA polymerases for certain task

ID: 213006 • Letter: W

Question

Why do cells maintain low fidelity, error prone DNA polymerases for certain tasks when more accurate, high fidelity DNA polymerases are available? gh fidelity DNA polymerases exclusively engage in DNA repair once synthesis is complete. There are far more low fidelity DNA polymerases available, and the cell recruits the first available polymerase. Distortions in the DNA template strand stall synthesis by high fidelity polymerases and recruiting low fidelity polymerases allows replication to continue. cells from previous generations. Low fidelity DNA polymerases are much faster than high fidelity DNA polymerases, which OLow fidelity DNA polymerases are not utilized in DNA synthesis but have remained in human always replicate DNA slowly

Explanation / Answer

The high fidelity polymerases, including DNA polymerase III are sensitive to distortions in the DNA template, while low-fidelity Y-family DNA polymerases are having the ability to traverse replication-blocking lesions. Hence, the answer for this question is Distortions in the DNA template strand stall synthesis by high fidelity polymerases and recruiting low fidelity polymerases allows replication to continue.

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