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rning.com/ibiscms/mod/ibis/view.php?id-4835630 Jun Gra 3/2018 11:59 PM CalculatorPeriodic Table on 9 of 12 Map netics: A Conceptual Approac Amy Huime at Missouri State University for metabolizing the In humans the LCT gene encodes the enzyme lactase which is disaccharide lactose. Lactase catalyzes the first step in the metabolism of lactose by breaking lactose into the monosaccharides glucose and galactose. Glucose and galactose are then broken down to form ATP by cellular respiration (more on this later in the Carbohydrates Module) To study LCT gene expression, you sequence a 1 kilobase region surrounding the transcription start site. Which of the following would you expect to find? (check all that are correct) an A block and a C block for TFIID to bind a TATA box to bind TFIID the -10 and -35 sequences for TFIID to bind an operator sequence for lac repressor to bind binding sites for ancillary transcription factors to bind AAUAAA for CPSF to bind Many adults become lactose intolerant later in life, which is thought to be due to changes in transcription of the LCT With this hypothesis, you sequence the LCT gene and more of its surrounding genomic sequence in several tolerant and lactose intolerant individuals. You find a number of single basepair mutations only in the lactose intolerant individuals. These mutations are not in the LCT gene, but are located 10-20 kilobases upstream of the gene in the introns of the MCM6 gene (pictured below as bolded nucleotides with slash marks, example- G/A). o searchExplanation / Answer
To study the LCT gene expression. The factors that are expected to be found are.
A TATA box to bind TFIIB because it initiates the process.
An operater sequence for lac repressor to bind varies with the presence of lactose. This is found only when lactose is present.
Binding sites for ancillary transcription factors to bind are also found.
Whereas the other options cannot be found in LCT gene expression such as A block and C block. And also -10 and -35 sequences the TFIIB cannot bind. And also the amino acid sequence for CPSF to bind cannot be expected.
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