Determine whether each statement is True or False 1.Needleman-Wunsch algorithm i

ID: 213600 • Letter: D

Question

Determine whether each statement is True or False

1.Needleman-Wunsch algorithm is most commonly used for local sequence alignment.

2.BLOSUM substitution matrix is the first set of amino acid substitution matrices.

3.In a pairwise sequence alignment, gaps are usually penalized in the calculation of alignment scores.

4.In both PAM and BLOSUM substitution matrices, pairs of amino acids that possess significantly different properties tend to have negative scores.

5.A high BLOSUM numbered matrix (e.g. BLOSUM90) should be used for the alignment of divergent protein sequences.

1. False.
Needleman-Wunsch algorithm is used for global alignment

2. True.
BLOSUM matrices are used to score alignments between evolutionarily divergent protein sequences, based on local alignments.

3. True.

4.True.

5. False.
It can be used for short alignments that are highly similar.

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