2.The first human oncovirus was discovered in 1964. Today, a \"tumor virus\" or
ID: 213994 • Letter: 2
Question
2.The first human oncovirus was discovered in 1964. Today, a "tumor virus" or "cancer virus" is any virus with a DNA or RNA genome that can cause cancer. Hence, they are classified as either "DNA oncovirus" or "RNA oncovirus". Research them, then choose one. Using no more than two paragraphs (1/2 page max, single-spaced), briefly explain the basic mechanisms of action by which the virus you chose causes cancer (you may refer to lecture slides at the end of L15, but make sure that your search goes beyond that). Cite your source of information at the end of your answer.Explanation / Answer
RNA oncovirus
Oncoviruses are the viruses that would be causing cancer. These are also referred to as oncornavirus. The mode of replication of the RNA viruses were initially thought to be similar to RNA viruses that were single stranded, but this was later replaced by the theory of reverse transcription. This virus consists of three primary domains:
The entry is through a glycoprotein attachment which is present on the surface. The process of reverse transcription occurs after the virus has entered the cell. This takes place in the cytoplasm so as to generate a dsDNA which is the genome’s copy. Also, there is production of long terminal repeats (LTRs) which are identical structures. LTRs would be present at DNA strand ends and carry Out regulation of the expression if the viral gene. This viral DNA will get translocated in the nucleus. In this, enzyme integrase or virion integrase inserts one strand of retrovirqk genome in the DNA of the host. Norm the retrovirus becomes provirus. After entering the chromosomal DNA the RNA pol II present in the cell would transcribe it. This would result in formation of full length progeny RNA visions. These would assemble in cytoplasm.
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