B. (30pts.) High-affinity immunoglobulin G1 (IgG1) antibodies to the M. tubercul

Question

B. (30pts.) High-affinity immunoglobulin G1 (IgG1) antibodies to the M. tuberculosis ESAT-6 virulence factor are often found in patients with active pulmonary TB. M. tuberculosis infects the lung. Briefly draw or describe how IgG1 antibodies to ESAT-6 might be generated by a patient's immune system. llustrate and add a few words describing the appropriate antigen presentation pathway(s), MHC complexes, antigen- presenting cells, T cells, B cells, cytokines, antibody isotypes and somatic mutations that generate anti-ESAT-6 immunoglobulin IgG1. (example reference: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC30230411) Signal sequence C terminus CFP-10 Nature Reviews Microbiology The ESAT-6/CFP-10 virulence complex

Explanation / Answer

Mycobacterium tuberculosis have specific virulence factor known as ESAT-6 that induces T cell and responsible for cell-mediated immunity against tuberculosis. ESAT-6 interact with some host cellular factors. It is found that host protein beta-2-microglobulin is an important protein that show interaction with ESAT-6 in C-terminal region and is secreted along with CFP-10 which is a chaperone protein. The complex of ESAT-6 and CFP-10 is found to decrease by MHC-I molecules classical and cross presentation of peptide antigens. The complex too enter the endoplasmic reticulum to inhibit expression of MHC-I-2M complexes, which finally resulted in class I-mediated antigen presentation down regulation.

Related Questions

Navigate

• Browse (All)
• Browse B
• Subjects

---

---

Integrity-first tutoring: explanations and feedback only — we do not complete graded work. Learn more.