Zika Virus Pathogenesis within the Nervous System\", discussed the suggestion of
ID: 214246 • Letter: Z
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Zika Virus Pathogenesis within the Nervous System", discussed the suggestion of immunopathology in the setting of impaired distinctive resistance. Their data provided a gripping basis in the investigation of T-cells and BBB breakdown within ZIKV-induced neurological complications that follow ZIKV infections in humans. Using lab mice and the virus first hand her research team concluded the systemic spread from site of infection to brain requires ifnar deficiency in hematopoietic compartment. Along with the spread of ZIKV within central nervous system is supported by non-hematopoietic cells. The ZIKV infection of astrocytes resulted in a breakdown of blood brain barrier and influx of CD8+effector T cells causing CD8+ T cell- induced death of infected neurons. Which then limited viral replication but in parallel causes ZIKV, associated paralysis in the victim.Explanation / Answer
"Zika virus pathogenesis within the Nervous system" is related to cell biology from some aspects like-
Regulation of gene expression-expression of ifnar1 gene is important for spread of Zika virus from site of infection to brain.If this can is deficient in hematopoeitic component then Zika virus can spread successfully. So expression of this gene or ifnar1 knock-in mice can prevent this Zika-virus mediated pathogenesis.
Transport across membranes-Transport of Zika virus from the site of infection to nervous system requires transport across cell membranes in tissues of different organs (like brain) or intestinal epithelial cells etc.
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