The cell cycle progresses via the activation of CDKs during different stages of

Question

The cell cycle progresses via the activation of CDKs during different stages of the cell cycle. CDKs are activated when they bind to cyclins, which are expressed and then degraded at the appropriate times. However, checkpoint proteins, including Wee1 kinase, can modify CDKs when they are bound to cyclins to inhibit their activity and delay cell cycle progression. Weel1 phosphorylates and inhibits the activity of CDK1, an M-phase CDK whose activity is required for progress from S/G2 to M-phase. 1) How does a cell inhibit Wee1, and how does this lead to a feed forward mechanism that enables progression to M-phase? (2 points) a) cancer cell death? (3 points)

Explanation / Answer

Ans-A wee 1 is inactivated by the Nim1 and Cdr1 by phosporylation of wee 1 at C terminus. After this Cdc25 is activated and wee1 got inactivated.

Ans-B the cancer cells die because the activated wee1 inhibit the cell growth. The s/G2 to M phase progression is inhibited due to wee1 activity and cell become unable to grow.

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