Question 34 What do alkylating agents do? They cause pyrimidine dimers. They add
ID: 214700 • Letter: Q
Question
Question 34
What do alkylating agents do?
They cause pyrimidine dimers.
They add methyl or ethyl groups to bases.
They oxidize guanine.
They deaminate cytosine.
They can do all of the above.
1 points
Question 35
A nonreplicative transposon does not leave a copy at its original site upon transposition. In contrast, a replicative transposon:
leaves two copies at the original site.
creates an original copy and a new one in the genome.
leaves two copies at the new insertion site.
replicates itself at the original site but does not create a new copy in the genome.
leaves a deletion at the original site.
1 points
Question 36
What is the result of strand slippage on the newly synthesized strand of DNA?
It will result in an insertion.
It will result in a transversion.
It will result in a transition.
It will result in a transposition.
It will not have any effect.
1 points
Question 37
In the mismatch repair mechanism, the parental strand is identified by:
methylation.
acetylation.
strand specific nicks.
double strand breaks.
bulky lesions.
They cause pyrimidine dimers.
They add methyl or ethyl groups to bases.
They oxidize guanine.
They deaminate cytosine.
They can do all of the above.
Explanation / Answer
Answer 34. Alkylating agents are the anticancer agents that exhibit their anticancer potential by oxidizing Guanine animo acid at the number 7 nitrogen atom in the purine ring. Crosslinking of Guanine in this way inhibits the ability of DNA to uncoil during DNA replication and as a result cells are no longer able to divide and eventually die.
Answer 35. Replicative transposition creates an original copy and a new one in the genome. Tn3 transposon is an example of replicative transposon.
Answer 36. Strand slippage results in an insertion. During stand slippage due to the presence of tandem repeats. DNA polymerase halts replication for some time when it encounters tandem repeat sequences the new strand detaches and pairs with some other tandem repeat sequences upstream and meanwhile DNA polymerase reassembles itself to strand and resumes replication. This results in faulty replication with insertion mutation. Huntington disease is an example of this type of mutation.
Answer 37. Mismatch repair mechanism is the repair machinery of the cell in which recognition and repair of erroneous DNA insertion and deletion occurs. The parental strand is methylated in DNA mismatch repair. Mismatch repair is strand specific and daughter strand commonly include errors.
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