31. There is evidence to suggest that in people with Alzheimer\'s disease (senil

Question

31. There is evidence to suggest that in people with Alzheimer's disease (senile dementia), the neurotransmitter acetylcholine is less available in many areas of the brain. If this hypothesis were true, you would correctly predict that in affected areas of an Alzheimer patient's, brain          .

a) neuron to neuron communication would decrease

b) neuron to neuron communication would increase

c) neurotransmitter concentration in the synapses would increase

d) neurotransmitter reception by the postsynaptic neuron would be blocked by acetylcholine

e) neurotransmitter reception by the postsynaptic neuron would increase

32. Physostigmine (a product of the calabar bean) has been investigated for treatment of people with Alzheimer's disease. You would correctly hypothesize that this has been done because physostigmine

a) can cause paralysis, which stimulates the brain ________________.

b) prevents muscle contraction so that the person who is sick can be more relaxed

c) stimulates acetylcholinesterase release in the synapse

d) keeps Na+ gates of axons permanently open

e) would prolong the action of acetylcholine in the synapses of the affected part of the brain

Explanation / Answer

31) In alzeihmer's disease, the neuron to neuron communication would decrease. This disease destroys neurons and their connections in parts of the brain involved in memory. It also affects areas in the cerebral cortex which is responsible for language, reasoning and social behaviour.

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