Changes in genetic sequences, or mutations, can result fom vanious types of dama

Question

Changes in genetic sequences, or mutations, can result fom vanious types of damage. The damage may be minor to extensive afterations in the DNA Correspondingly, apter mutations may result in no phenotypic change or in phenotypic changes ranging from minor with little impact on fitness to severe enough to destroy a gene product and compromise an organism's ability to sunvive. apter Part A- The eflects of point mutations on potypeptides apter Point mutations are those that alter a single base pair or base location, and include substitutions and frameshift mutations. They can range in severity from no phenotypic change to complete loss of function. Rank the following point mutations in order of least damaging to most damaging if they occur in the middle of the coding sequence of a relab polypeptide. View Available Hintts) reLab 1 Reset Help Frameshift MssenseNonsense Silent Lab Qui Lecture Respond Most damaging Least damaging Post Lab Post Lab Post Lab

Explanation / Answer

Least Dmaging to Most damaging orfer of mutations

Silent mutation < Missense mutation < Nonsense mutation < Frameshift mutations

In silent mutation, the altered gene sequence still codes for the same amino acid hence no change in the protein sequence.

Missense mutations result in the change of one base pair which results in substitution of one amino acid only.

Nonsense mutation, the substituted base pair results into change of normal codon to stop codon which results into production of short or truncated protein which are usually non functional.

Frameshift mutations are those in which the whole reading frame changes due to addition or deletion of base pair which results into production of a new protein sequence which is not funtional at all.

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