Gene A with 4 exons, codes for a liver enzyme. This gene has three alleles; A1,
ID: 215668 • Letter: G
Question
Gene A with 4 exons, codes for a liver enzyme. This gene has three alleles; A1, A2 and A3. A1A1 individuals are normal and produce 500 units of the functional enzyme. A1A3 patients produce 250 units of the functional enzyme. Based on this information, which of the following cannot be the cause of generation of allele A3?
A base deletion in exon-2 of gene A
A silent mutation in exon-1 of gene A
A mutation that deleted the start codon
A mutation in the promoter of gene A
A splice site mutation in the first intron
A.A base deletion in exon-2 of gene A
B.A silent mutation in exon-1 of gene A
C.A mutation that deleted the start codon
D.A mutation in the promoter of gene A
E.A splice site mutation in the first intron
Explanation / Answer
The correct answer should be
A silent mutation in exon-1 of gene A
because silent mutation is a base substitution in such a way that the amino acid sequence is not affected when altered mRNA is translated while all the rest of the types of mutations would all result in either the production of incomplete protein or no production at all.
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B.A silent mutation in exon-1 of gene A
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