Which of the following can lead to a change in shape and thus a change in activi

Question

Which of the following can lead to a change in shape and thus a change in activity? A phosphatase removes a phosphate from a protein O A protein kinase gets phosphorylated O A ligand binds a receptor O cAMP binds a protein kinase O G protein hydrolyzes GTP DQuestion 4 1 pts Which of the following are proteins? O cAMP O Ca2+ O Adenylyl cyclase Protein Kinase Tyrosine Kinase Receptor DQuestion 5 1 pts Which of the following need to be "specific for cell signaling to be a targeted event On other words, which of the following allow for specificityl)? O the target cell receptor D relay molecules in target cell the ligand

Explanation / Answer

3. When a ligand binds to a receptor protein, it alters the chemical conformation by affecting the three-dimensional shape orientation. The conformation of a receptor protein composes the functional state.

When a ligand activates the G protein-coupled receptor, it induces a conformational change in the receptor that allows the receptor to function as a guanine nucleotide exchange factor (GEF) that exchanges GDP for GTP – thus turning the GPCR "on".

4. Recptors and enzymes are protein in nature. GPCR, Adenylyl cyclase, protein kinase, tyrosine kinase receptor all are protein in nature.

5. Both target cell receptor and the ligand.

Receptors and ligands come in many forms, but they all have one thing in common: they come in closely matched pairs, with a receptor recognizing just one (or a few) specific ligands, and a ligand binding to just one (or a few) target receptors.

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