(1) Assume you have visited a population of 500 people in remote Southeast Asia.

Question

(1) Assume you have visited a population of 500 people in remote Southeast Asia. After having survived bouts of jungle fever and foot rot, you have painstakingly determined the following genotype numbers for the RS blood group system: RR 112, RS 43, SS 345 Is this population in Hardy-Weinberg equilibrium? If not, what factor(s) are most likely responsible for the difference between observed and expected genotype numbers? Evaluate each assumption for equilibrium and each force of evolution for possible influence here. Be sure to support your hypothesis

Explanation / Answer

Answer:

Based on the given data:

Genotypes for RS blood group system:

Determination of Expected Genotype Frequencies:

To determine if the population is in Hardy-Weinberg Equilibrium or not, a Chi Square test can be performed.

Degree of freedom = Number of categories -1 = 3 - 1 = 2

P-value corresponding to Chi Square value of 304.5 for 2 degree of freedom is: P-Value is < 0.00001. The result is significant at p < 0.05.

Therefore, Null Hypothesis is rejected, the population is NOT in Hardy Weinberg Equilibrium.

Genotype Observed (O) Expected (E) (O-E) (O-E)^2/E RR 112 35.6 76.36 163.6 RS 43 195.7 -152.71 119.2 SS 345 268.6 76.36 21.7 Total 500 500 Chi Square (sum) 304.5

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