What changes in fatty acid metabolism would result from a mutation in the muscle

Question

What changes in fatty acid metabolism would result from a mutation in the muscle carnitine acyltransferase I in which the mutant protein has lost its affinity for malonyl-CoA but not its catalytic activity?

A. Fatty acid synthesis in the mitochondria and fatty acid oxidation in the cytosol could occur simultaneously.

B. Fatty acid synthesis in the cytosol and fatty acid oxidation in the mitochondria could occur simultaneously.

C. Synthesis of malonyl carnitine could only occur at high malonyl-CoA concentration.

D. Synthesis of malonyl-CoA would no longer be inhibited carnitine.

Explanation / Answer

The answer is B. i.e

Fatty acid synthesis in the cytosol and fatty acid oxidation in the mitochondria could occur simultaneously because malonyl-CoA would no longer inhibit Fatty acid entry into the mitochondria and beta -oxidation.

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