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lew 1.@. ùstore WB.?Bookmark art Screenshot My Add-ins Wikipedia Media t?DD.h' CommentHeader Footer Page Tex Cross-reference Number Part D) History of Genetic Studies 12) Hirschhorn and Daly (2005) describe genome-wide association studies (GWAS) as being superior in some instances to Mendelian linkage-based analyses. How do Hirschhom and Daly support this claim? Reference: Hirschhorn, J. N., & Daly, M. J. (2005). Genome-wide association studies for common diseases and complex traits. Nature Reviews Genetics, 6(2), 95-108. 13) Describe DisGeNet in terms of its construction and features. Based on the article, as described by the authors, what specific aspects of it make it better than other SNP databases? Reference: Piñero, J., Queralt-Rosinach, N., Bravo, A., Deu-Pons, J., Bauer- Mehren, A., Baron, M., & Furlong, L. I. (2015). DisGeNET: a discovery platform for the dynamical exploration of human diseases and their genes. Database, 2015, bav028.Explanation / Answer
Answer 12) Hirschhorn and Daly describe in his reseasrch that genes affect strongly some common diseases and identify the causal gene is difficult because genes make small contribution in transmission of characters(heredity).Genome wide Association studies provide a powerful approach in mapping of causal genes in an individual. So, it will be easy to identify the causal gene.
Mendelian linkage based analysis could not be able to identify the specific causal gene.
Answer 13) SNP(Single Nucleotide Polymorphism) is a variation in a single nucleotide which occurs at specific genome . So, SNP database only provide the single nucleotide variation information.But DisGeNet is a powerful plateform which provide wide range of genes for various diseases which can be easily available for comparison and identification of the genes.
The specific aspects are:
It covers Mendelian and complex diseases.
It is based on supporting evidence to gene-disease asssociation.
It is an open resource with web access interface which support user friendly data exploration and navigation.
It provide clear and detail information regarding its origin which allows the user to compare with the original information.
It allows easy browsing and downloading of information related to diseases.
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